翻訳と辞書 Words near each other ・ Ribose 1-dehydrogenase (NADP+) ・ Ribose 5-phosphate ・ Ribose isomerase ・ Ribose repressor ・ Ribose-5-phosphate adenylyltransferase ・ Ribose-5-phosphate isomerase ・ Ribose-5-phosphate isomerase deficiency ・ Ribose-5-phosphate—ammonia ligase ・ Ribose-phosphate diphosphokinase ・ Riboside ・ Ribosomal binding site ・ Ribosomal DNA ・ Ribosomal frameshift ・ Ribosomal Intergenic Spacer analysis ・ Ribosomal L28e protein family ・ Ribosomal pause ・ Ribosomal protein ・ Ribosomal protein L10 leader ・ Ribosomal protein L13 leader ・ Ribosomal protein L19 leader ・ Ribosomal protein L20 leader ・ Ribosomal protein L21 leader ・ Ribosomal protein L4 ・ Ribosomal protein L5 ・ Ribosomal protein leader ・ Ribosomal protein S19 ・ Ribosomal protein s6 ・ Ribosomal protein SA ・ Ribosomal rescue factor ・ Ribosomal RNA Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Ribosomal pause ： ウィキペディア英語版 Ribosomal pause Ribosomal pause refers to the queueing or stacking of ribosomes during translation of the nucleotide sequence of mRNA transcripts. These transcripts are decoded and converted into amino acid sequence during protein synthesis by ribosomes. Within the ribosome, transfer RNA molecules recognise specific trinucleotide codons on the mRNA, and add their cognate amino acids to nascent protein chains.〔Jha SS, Komar AA. Isolation of ribosome bound nascent polypeptides in vitro to identify translational pause sites along mRNA. J Vis Exp. 2012 Jul 6;(65). pii: 4026. doi: 10.3791/4026.〕〔(John D. Lopinski ), Jonathan D. Dinman, Jeremy A. Bruenn. Kinetics of Ribosomal Pausing during Programmed −1 Translational Frameshifting. Mol. Cell. Biol. February 2000 vol. 20 no. 4 1095-1103.〕 It’s been known since the 1980s that different mRNAs are translated at different rates. The main reason for these differences was thought to be the concentration of rarer varieties of tRNA limiting the rate at which some transcripts could be decoded.〔Harry Kontos†, Sawsan Napthine, and Ian Brierley, Harry Kontos, Sawsan Napthine, and Ian Brierley. Ribosomal Pausing at a Frameshifter RNA Pseudoknot Is Sensitive to Reading Phase but Shows Little Correlation with Frameshift Efficiency. Mol. Cell. Biol. December 2001 vol. 21 no. 24 8657-8670〕 == Effects on gene expression == During protein synthesis, rapidly changing conditions in the cell can cause ribosomal pausing. In bacteria and viruses, this can affect growth rate and trigger translational abandonment. This releases the ribosome from the mRNA and the incomplete polypeptide is targeted for destruction.〔Buchan JR, Stansfield I. Halting a cellular production line: responses to ribosomal pausing during translation. Biol Cell. 2007 Sep;99(9):475-87.〕 In eukaryotes, ribosomal pausing can initiate an analogous process which triggers endonucleolytic attack of the mRNA, a process termed mRNA no-go decay. Ribosomal pausing also aids co-translational folding of the nascent polypeptide on the ribosome, and delays protein translation while its encoding mRNA. This can trigger ribosomal frameshifting.〔Buchan JR, Stansfield I. Halting a cellular production line: responses to ribosomal pausing during translation. Biol Cell. 2007 Sep;99(9):475-87.〕 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Ribosomal pause」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.